Skip to Main Content

All Roseman University campuses will close on Tuesday, November 26, at 5 pm for Fall Break. Campuses will reopen for regular
hours on Monday, December 2.

Search the Literature

Instruction for building a search strategy, recording searches and managing results.

How Do I Formulate a Question?


A well structured question will help you:

  • select search terms
  • decide which database to search
  • figure out what results to exclude

PICO Question Format

PICO is a clinical question format for Evidence-Based Practice. This question format includes four components:

P = Patient/Population/Problem

The most clinically relevant characteristics of this patient, population, or problem.

I = Intervention

The intervention you are considering in relation to the patient/population, such as therapy, diagnostic method, prognostic factor, etc.

C = Comparison

An alternative intervention or the control (no action or the current standard of care). Sometimes left out of a question.

O = Outcome

Measurable impact, change, or improvement.

The chart below comes from the Center for Evidence-Based Medicine's guide on asking a focused question.

Chart of tips and examples for building a PICO question

There are other methods for structuring and formatting a question. If PICO doesn't work for you or the type of question you are asking, try one of these other formats.