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Search the Literature

Instruction for building a search strategy, recording searches and managing results.

Search Terms


Searching for information is always iterative - you try, adjust, and try again. This is especially true for search terms.

Search terms should represent the primary concepts of your question. If you built a good PICO question, you should already have the basic concepts for your search.

Create a list:

  • synonyms
  • alternate spellings (e.g. British versus American English)
  • punctuation (hyphen or no hyphen)
  • acronyms and spelled out acronyms
  • narrower & broader terms
  • plural and singular

Use subject matter words only.

Do not use:

  • comparative words (effect, impact, reaction, cause)
  • prepositions (during, due to, within, without)
  • interrogative words (e.g. how, when, why, what)

These are often called "stopwords". There is a list of all the stopwords in PubMed.

Synonyms & Term Mapping


You can make a grid or a map to help you visualize multiple search terms.

Grid

EXAMPLE PICO Question: In post-menopausal women does hormone replacement therapy compared to no HRT increase the risk of breast cancer?

Patient/Problem

Intervention Comparison Outcome
post-menopausal women hormone replacement therapy no hormone replacement therapy increased risk of breast cancer

post menopause

post-menopause

post menopausal

post-menopausal

postmenopause

postmenopausal

hormone replacement therapy

HRT

menopausal hormone therapy

MHT

estrogen replacement therapy

estrogen progestin replacement therapy

 

breast cancer

breast carcinoma

breast tumors

breast neoplasm

mammary cancer

 

Map

Maps can be handwritten, making them a fast method for visual thinkers.

Image: visual map of the search term written in bubbles

 

Keywords or Subject Headings?


For a quick search, we recommend that you primarily rely on searching by keywords. If that is unsuccessful, you can try searching by subject headings or ask a librarian for help.

More advanced literature searches should use both keywords and subject headings.

Keywords = "natural language"

The terms you would naturally use to speak about and describe concepts. This includes both common language and medical or health sciences terminology you would use with fellow practitioners.

Databases generally locate those keywords in the title, journal name, author name, abstract, and their own specially applied keywords and subject headings in the article records. They generally will NOT search the full text of the article.

Subject Headings = "controlled vocabulary"

A set of standardized words that a database uses to describe concepts (e.g.: "breast neoplasm" to describe breast cancer or breast carcinoma). These preferred, standardized words are mapped to other variant terms for that concept and then applied to every single article in the database that discusses that concept.

To search by subject heading, use the database's thesaurus or medical subject heading (MeSH) search builder. PubMed will attempt to do this for you automatically if you search by keywords. Ask a librarian for help if you are not certain how to do this.